Changing DNS with systemd-resolved

The file /etc/resolv.conf contains the following lines:

# This file is managed by man:systemd-resolved(8). Do not edit.

So when we want to change the DNS settings we are going to change the file /etc/systemd/resolved.conf

#  This file is part of systemd.
#
#  systemd is free software; you can redistribute it and/or modify it
#  under the terms of the GNU Lesser General Public License as published by
#  the Free Software Foundation; either version 2.1 of the License, or
#  (at your option) any later version.
#
# Entries in this file show the compile time defaults.
# You can change settings by editing this file.
# Defaults can be restored by simply deleting this file.
#
# See resolved.conf(5) for details

[Resolve]
DNS=192.168.88.22
FallbackDNS=8.8.8.8
Domains=yourdomain.local
#LLMNR=no
#MulticastDNS=no
...etc...

After that is done and you saved the file, you run from the command line:

service systemd-resolved restart

Now you can see the status of your changes

systemd-resolve --status

Now you should see:

Global
       LLMNR setting: no
MulticastDNS setting: no
  DNSOverTLS setting: no
      DNSSEC setting: no
    DNSSEC supported: no
  Current DNS Server: 192.168.80.20
         DNS Servers: 192.168.80.20
Fallback DNS Servers: 8.8.8.8
          DNS Domain: enovision.local
          DNSSEC NTA: 10.in-addr.arpa
                      16.172.in-addr.arpa
                      168.192.in-addr.arpa
                      ... etc ...           

Better alternative

sudo systemd-resolve --interface wlp2s0 --set-dns 192.168.88.22 --set-domain yourdomain.local

where wlp2s0 is the name of your (wireless) network card. You can easily check this with ifconfig